IFF Pharma Solutions Unveils Breakthrough Research at AAPS 2024 PharmSci 360

In a significant development for the pharmaceutical industry, IFF Pharma Solutions is set to showcase groundbreaking research at the American Association of Pharmaceutical Scientists (AAPS) 2024 PharmSci 360 conference. The event, which will take place in Salt Lake City, Utah, from October 20 to 23, promises to reveal pivotal advancements in excipient selection, drug delivery, and formulation processes.

The Role of Excipients in Drug Delivery

One of the primary focuses of IFF Pharma Solutions' research is the critical role of excipients in drug delivery. Excipients are inactive ingredients added to pharmaceutical formulations to enhance their stability, bioavailability, and overall efficacy. By leveraging their extensive expertise in polymers and excipients, IFF Pharma Solutions aims to equip pharmaceutical manufacturers with safer and more effective formulations.

Key Areas of Research

1. Nitrosamine Risk Reduction

   • IFF Pharma Solutions will present significant advancements in the selection of excipients aimed at reducing nitrosamine risks. Nitrosamines are potentially carcinogenic compounds that can form in certain drug products. The company’s research highlights strategies to minimize these risks, ensuring that pharmaceuticals are safer for patients.

2. Controlled-Release Formulations

   • The company will also showcase research on controlled-release formulations. This involves developing drugs that release their active ingredients at a predetermined rate, enhancing patient compliance and therapeutic outcomes. Key insights will be provided on how various excipients influence the kinetic profiles of these formulations.

3. Extrusion Spheronization Processability

   • Improvements in the extrusion spheronization process will be another highlight. This process is crucial for creating spherical particles used in tablet formulations. By optimizing this process, manufacturers can achieve better pellet quality and consistency, which is essential for reproducible drug delivery.

4. Softgel Stability and Plant-Based Gummies

   • IFF Pharma Solutions will also present research on softgel stability and the creation of plant-based pharmaceutical gummies. These innovative formats offer consumers more appealing choices while ensuring the stability and efficacy of the active ingredients.

Breakthrough Presentations

Several key presentations are scheduled to take place during the conference. These include:

1. "The Selection of Microcrystalline Cellulose Based Excipients in Spheronization"

   • Lead applications scientist Yeli Zhang will share fresh insights into immediate-release formulations utilizing microcrystalline cellulose. This excipient is widely used due to its inert properties and ability to enhance tablet disintegration.

2. "Vegetable Softgels Using Seaweed-Based Excipients for Pharmaceutical Applications"

   • Jin Zhao, Ph.D., lead scientist, will unveil a poster titled "Veget Softg Using Seaweed Technology for Pharmaceutical Applications." This presentation will highlight the superior heat tolerance and stability of plant-based softgels compared to traditional gelatin capsules under various aging conditions.

3. "Nitrite-Led Release Formulations for Water-Soluble Drugs"

   • Nasrin Mahmoudi, Ph.D., senior lead application scientist, will present a robust and safe controlled-release tablet formulation active pharmaceutical ingredient (API) containing vulnerable amines. This formulation aims to ensure the controlled release of water-soluble drugs, minimizing side effects and improving therapeutic outcomes.

4. "Analytical Advances in Measuring Nitrites in Pharmaceutical Excipients"

   • Koudi Zhu, analytical scientist, will discuss a sensitive two-ion chromatography-spectrometry (2-ICMS) technique for detecting nitrites in xanthan gum and hydroxypropyl methylcellulose (HPMC). This technique is crucial for ensuring the purity and safety of excipients used in pharmaceutical formulations.

5. "Predicting Hydrophilic Polymer Characteristics for Controlled-Release Matrix Tablets"

   • Mark Dreibelbis, research and scientist, will share insights on the hydrophilic polymer characteristics that can predict the controlled-release performance of matrix tablets. This presentation will focus on the role of hydrophilic polymers in matrix tablet formulation and their predictive value in ensuring consistent drug release.

Impact on the Pharmaceutical Industry

The research presented by IFF Pharma Solutions at AAPS 2024 PharmSci 360 has the potential to significantly impact the pharmaceutical industry. By advancing the understanding of excipients and their role in drug delivery, manufacturers can create safer and more effective formulations. This, in turn, can improve patient outcomes and enhance the overall quality of life for those relying on these medications.

Conclusion

The unveiling of IFF Pharma Solutions' breakthrough research at AAPS 2024 PharmSci 360 marks a significant milestone in the pharmaceutical industry. With a focus on excipient selection, controlled-release formulations, and analytical techniques, this research has the potential to revolutionize drug delivery and formulation processes. As the industry continues to evolve, it is crucial to stay at the forefront of innovation, and IFF Pharma Solutions is poised to lead the way.

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References

1. IFF Pharma Solutions Unveils Breakthrough Research at AAPS 2024
2. IFF Pharma Solutions Breakthrough Research at AAPS 2024
3. AAPS 2024 PharmSci 360